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KMID : 0352819890050010071
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Kosin Medical Journal
1989 Volume.5 No. 1 p.71 ~ p.85
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Effect of Cadmium Intoxication on Renal Glucose Transport System
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Abstract
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1
Effect of cadmium intoxication on the renal glucose transport system was studied. Subcutaneous injections of CdCl₂(2㎎ Cd/㎏.day) for 2-3weeks induced marked polyuria, glycosuria, and proteinuria without altering the glomerular filtration rate. In the renal cortical brush border membrane vesicles isolated from cadmium-treated rats, the Na+ -dependent D-glucose uptake was markedly attenuated, and this was due to the reduction in Vmax and not Km. On the other hand, the Na+ independent uptake of glucose was not apparently altered. In the basolateral membrane vesicles, the uptake and the efflux of D-glucose was not significantly affected by cadmium treatment.
These results indicated that cadmium intoxication impairs the Na+ -glucose contransport system in the brush border membrane of renal proximal tubular cell.
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